Wildfires emit a range of gases, including sulfur- and nitrogen-containing compounds, as well as particulate matter (PM) such as organic carbon and black carbon. These emissions can be transported long distances by wind and subsequently deposited onto soil and water surfaces. Both measurement and modeling studies indicate that smoke deposition can substantially contribute to total atmospheric deposition and can trigger rapid changes in ecosystem chemistry. However, wildfire occurrence, size, and intensity vary greatly across time and space, creating complex patterns in emissions and resulting depositions. This study characterizes the complexity by analyzing fire-deposition relationships and their temporal and regional patterns and differences between wet and dry depositions in the United States. The datasets used in this study included wildfires from the Monitoring Trends in Burn Severity (MTBS) program, wet depositions of eight parameters from the National Atmospheric Deposition Program (NADP) National Trends Network (NTN), and measurements of 12 parameters from the Interagency Monitoring of PROtected Visual Environments (IMPROVE) program which were used as proxies for dry depositions. Analyses of these datasets show that, despite generally opposite long-term trends over the past four decades in most U.S. Forest Service regions, years with intense wildfire activity often coincide with extreme values of chemical species, especially for dry depositions. Significant correlations with wildfires are observed for dry deposition species in nearly all regions and for certain wet deposition species in the western mountain regions. These correlations differ moderately between annual and fire-season averages but considerably across seasons. The seasons exhibiting the strongest correlations differ between wet and dry depositions and vary by region. Correlations are weak between wet and dry depositions, but strong among most wet deposition parameters in more than half regions and among dry deposition PM parameters in all regions. Overall, fire-deposition linkages are more pronounced for dry than wet deposition. These findings highlight the importance of accounting for wildfire-driven deposition variability and help improve understanding of uncertainties in NADP total deposition assessments.